{"id":18106,"date":"2022-09-10T11:00:25","date_gmt":"2022-09-10T11:00:25","guid":{"rendered":"https:\/\/mastermindcontent.co.uk\/?p=18106"},"modified":"2022-09-20T08:44:41","modified_gmt":"2022-09-20T08:44:41","slug":"depression-linked-with-chronic-stress-says-new-study","status":"publish","type":"post","link":"https:\/\/mastermindcontent.co.uk\/depression-linked-with-chronic-stress-says-new-study\/","title":{"rendered":"Depression Linked With Chronic Stress Says New Study"},"content":{"rendered":"\n
Dr Mohieldin Youssef, the lead researcher said “The presence of the gene helps with stress-resilience and if it’s removed, there’s an increase in depression, fear, and anxiety.\u201d<\/p>\n\n\n\n
Tob is named for the Japanese verb “tobu,” which means to fly or to jump. The gene is also known as the \u201cJumping Gene\u201d because protein levels jump in activity when the cell is exposed to a stimulus.<\/p>\n\n\n\n
For example, protein levels in the Tob increase when stimulated by acute stress. Youssef came to this conclusion after dropping mice into a bucket of water. <\/p>\n\n\n\n
Mice with the Tob gene swam around looking for ways to escape. Mice that were born without the Tob gene simply floated on the surface of the water. Researchers link giving up with depression. <\/p>\n\n\n\n
What we are seeing here is the classic fight-flight-freeze response which is associated with neural circuits in the hippocampus, prefrontal cortex, amygdala, and hypothalamus. <\/p>\n\n\n\n
The brain utilises several mechanisms to cope with psychological stress. At the molecular level, acute stress induces transcriptional and translation responses. <\/p>\n\n\n\n
When there is a defect in the genes, the mechanisms do not function as they’re supposed to. In the Japan study, it was identified that a lack of Tob gene activity in the hippocampus<\/a> increased levels of fear and anxiety.<\/p>\n\n\n\n The researchers also discovered that mice without the Tob gene \u201cdidn\u2019t seem to learn.\u201d When these mice were placed in an environment that aroused fear but ultimately turned out to be safe, the mice with inhibited Tob cells continued to show symptoms of fear. <\/p>\n\n\n